Deleterious effect of oltipraz on extrahepatic cholestasis in bile duct-ligated mice.

ABSTRACT:

Background & aims

Oltipraz (4-methyl-5(pyrazinyl-2)-1-2-dithiole-3-thione), a promising cancer preventive agent, has an antioxidative activity and ability to enhance glutathione biosynthesis, phase II detoxification enzymes and multidrug resistance-associated protein-mediated efflux transporters. Oltipraz can protect against hepatotoxicity caused by carbon tetrachloride, acetaminophen and alpha-naphthylisothiocyanate. Whether oltipraz has hepato-protective effects on obstructive cholestasis is unknown.

Methods

We administered oltipraz to mice for 5 days prior to bile duct ligation (BDL) for 3 days. Liver histology, liver function markers, bile flow rates and hepatic expression of profibrogenic genes were evaluated.

Results

Mice pretreated with oltipraz prior to BDL de

SUBMITTER: Weerachayaphorn J 

PROVIDER: S-EPMC4054607 | biostudies-literature | 2014 Jan

REPOSITORIES: biostudies-literature