Use of corticosteroids during pregnancy and risk of asthma in offspring: a nationwide Danish cohort study.

ABSTRACT:

Objective

To examine whether in utero exposure to local and systemic corticosteroids is associated with asthma development in offspring.

Design

Cohort study.

Setting

Denmark.

Participants

We included all singletons born alive in Denmark between 1996 and 2009. Data on maternal corticosteroid use, asthma in offspring and covariates were obtained from medical registries.

Main outcome measures

We compared asthma risks of children prenatally exposed to corticosteroids and of children of former corticosteroid users with that of unexposed children. We computed absolute risks and used proportional-hazards regression to compute adjusted HRs (aHRs). Using logistic regression we compared exposed children with unexposed siblings in a 'within-mother-between-pregnancy

SUBMITTER: Byrjalsen A 

PROVIDER: S-EPMC4054622 | biostudies-literature | 2014 Jun

REPOSITORIES: biostudies-literature