Impact of comorbidity on risk of venous thromboembolism in patients with breast cancer: a Danish population-based cohort study.

ABSTRACT:

Objectives

To assess the interaction between comorbidity and breast cancer (BC) on the rate of venous thromboembolism (VTE) beyond what can be explained by the independent effects of BC and comorbidity.

Design

Population-based matched cohort study.

Setting

Denmark.

Participants

Danish patients with BC (n=62 376) diagnosed in 1995-2010 and a comparison cohort of women without BC (n=304 803) from the general population were matched to the patients with BC on year of birth in 5-year intervals and on the specific diseases included in the Charlson Comorbidity Index (CCI) and atrial fibrillation and obesity.

Measures

The rate ratios of VTE per 1000 person-years (PY) were computed by comorbidity levels using the CCI, and interaction contrasts (IC) were calculat

SUBMITTER: Ording AG 

PROVIDER: S-EPMC4054647 | biostudies-literature | 2014 Jun

REPOSITORIES: biostudies-literature