Dynamics of chromatin accessibility and gene regulation by MADS-domain transcription factors in flower development.

ABSTRACT:

Background

Development of eukaryotic organisms is controlled by transcription factors that trigger specific and global changes in gene expression programs. In plants, MADS-domain transcription factors act as master regulators of developmental switches and organ specification. However, the mechanisms by which these factors dynamically regulate the expression of their target genes at different developmental stages are still poorly understood.

Results

We characterized the relationship of chromatin accessibility, gene expression, and DNA binding of two MADS-domain proteins at different stages of Arabidopsis flower development. Dynamic changes in APETALA1 and SEPALLATA3 DNA binding correlated with changes in gene expression, and many of the target genes could be associated with t

SUBMITTER: Pajoro A 

PROVIDER: S-EPMC4054849 | biostudies-literature | 2014 Mar

REPOSITORIES: biostudies-literature