PTTG1 overexpression in adrenocortical cancer is associated with poor survival and represents a potential therapeutic target.

ABSTRACT:

Background

Adrenocortical carcinoma (ACC) is associated with poor survival rates. The objective of the study was to analyze ACC gene expression profiling data for prognostic biomarkers and therapeutic targets.

Methods

We profiled 44 ACC and 4 normal adrenals on Affymetrix U133 Plus 2 expression microarrays. Pathway and transcriptional enrichment analysis was performed. Protein levels were determined by Western blot. Drug efficacy was assessed against ACC cell lines. Previously published expression datasets were analyzed for validation.

Results

Pathway enrichment analysis identified marked dysregulation of cyclin-dependent kinases and mitosis. Overexpression of PTTG1, which encodes securin, a negative regulator of p53, was identified as a marker of poor survival. Media

SUBMITTER: Demeure MJ 

PROVIDER: S-EPMC4054940 | biostudies-literature | 2013 Dec

REPOSITORIES: biostudies-literature