Evaluation of islets derived from human fetal pancreatic progenitor cells in diabetes treatment.

ABSTRACT:

Introduction

With the shortage of donor organs for islet transplantation, insulin-producing cells have been generated from different types of stem cell. Human fetal pancreatic stem cells have a better self-renewal capacity than adult stem cells and can readily differentiate into pancreatic endocrine cells, making them a potential source for islets in diabetes treatment. In the present study, the functions of pancreatic islets derived from human fetal pancreatic progenitor cells were evaluated in vitro and in vivo.

Methods

Human pancreatic progenitor cells isolated from the fetal pancreas were expanded and differentiated into islet endocrine cells in culture. Markers for endocrine and exocrine functions as well as those for alpha and beta cells were analyzed by immunofluoresc

SUBMITTER: Zhang WJ 

PROVIDER: S-EPMC4055010 | biostudies-literature | 2013

REPOSITORIES: biostudies-literature