Genome-wide association and pharmacological profiling of 29 anticancer agents using lymphoblastoid cell lines.

ABSTRACT:

Aim

Association mapping with lymphoblastoid cell lines (LCLs) is a promising approach in pharmacogenomics research, and in the current study we utilized LCLs to perform association mapping for 29 chemotherapy drugs.

Materials & methods

Currently, we use LCLs to perform genome-wide association mapping of the cytotoxic response of 520 European-Americans to 29 different anticancer drugs; the largest LCL study to date. A novel association approach using a multivariate analysis of covariance design was employed with the software program MAGWAS, testing for differences in the dose-response profiles between genotypes without making assumptions about the response curve or the biologic mode of association. Additionally, by classifying 25 of the 29 drugs into eight families according

SUBMITTER: Brown CC 

PROVIDER: S-EPMC4055088 | biostudies-literature | 2014 Feb

REPOSITORIES: biostudies-literature