A short-term treatment with tumor necrosis factor-alpha enhances stem cell phenotype of human dental pulp cells.

ABSTRACT:

Introduction

During normal pulp tissue healing, inflammatory cytokines, such as tumor necrosis factor-alpha (TNF-α) or interleukins, act in the initial 48 hours (inflammatory phase) and play important roles not only as chemo-attractants of inflammatory cells and stem/progenitor cells but also in inducing a cascade of reactions toward tissue regeneration or reparative dentin formation or both. Previous reports have shown that inflammatory cytokines regulate the differentiation capacity of dental pulp stem/progenitor cells (DPCs), but none has interrogated the impact of these cytokines on the stem cell phenotype of stem/progenitor cells. This study investigated the effects of a short-term treatment with TNF-α on the stem cell phenotype and differentiation ability of human DPCs.

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SUBMITTER: Ueda M 

PROVIDER: S-EPMC4055131 | biostudies-literature | 2014 Feb

REPOSITORIES: biostudies-literature