Ethanol self-administration and nicotine treatment increase brain levels of CYP2D in African green monkeys.

ABSTRACT:

Background and purpose

CYP2D6 metabolizes many centrally acting drugs, neurotoxins and endogenous neurochemicals, and differences in brain levels of CYP2D have been associated with brain function and drug response. Alcohol consumers and smokers have higher levels of CYP2D6 in brain, but not liver, suggesting ethanol and/or nicotine may induce human brain CYP2D6. We investigated the independent and combined effects of chronic ethanol self-administration and nicotine treatment on CYP2D expression in African green monkeys.

Experimental approach

Forty monkeys were randomized into control, ethanol-only, nicotine-only and ethanol + nicotine groups. Two groups voluntarily self-administered 10% ethanol in sucrose solution for 4 h·day(-1) , whereas two groups consumed sucrose solutio

SUBMITTER: Miller RT 

PROVIDER: S-EPMC4055207 | biostudies-literature | 2014 Jun

REPOSITORIES: biostudies-literature