Comparative analysis of human tissue interactomes reveals factors leading to tissue-specific manifestation of hereditary diseases.

ABSTRACT: An open question in human genetics is what underlies the tissue-specific manifestation of hereditary diseases, which are caused by genomic aberrations that are present in cells across the human body. Here we analyzed this phenomenon for over 300 hereditary diseases by using comparative network analysis. We created an extensive resource of protein expression and interactions in 16 main human tissues, by integrating recent data of gene and protein expression across tissues with data of protein-protein interactions (PPIs). The resulting tissue interaction networks (interactomes) shared a large fraction of their proteins and PPIs, and only a small fraction of them were tissue-specific. Applying this resource to hereditary diseases, we first show that most of the disease-causing genes are widel

SUBMITTER: Barshir R 

PROVIDER: S-EPMC4055280 | biostudies-literature | 2014 Jun

REPOSITORIES: biostudies-literature