Genetic modifiers of cardiorespiratory fitness response to lifestyle intervention.

ABSTRACT:

Purpose

Numerous prospective studies indicate that improved cardiorespiratory fitness reduces type 2 diabetes risk and delays disease progression. We hypothesized that genetic variants modify fitness response to an intensive lifestyle intervention (ILI) in the Action for Health in Diabetes (Look AHEAD) randomized clinical trial, aimed to detect whether ILI will reduce cardiovascular events in overweight/obese subjects with type 2 diabetes compared with a standard of care.

Methods

Polymorphisms in established fitness genes and in all loci assayed on the Illumina CARe iSelect chip were examined as predictors of change in MET level, estimated using a treadmill test, in response to a 1-yr intervention in 3899 participants.

Results

We identified a significant signal in pre

SUBMITTER: Peter I 

PROVIDER: S-EPMC4055466 | biostudies-literature | 2014 Feb

REPOSITORIES: biostudies-literature