Metabolic complications of in utero maternal HIV and antiretroviral exposure in HIV-exposed infants.

ABSTRACT:

Background

Despite a wide body of literature supporting the use of antenatal antiretrovirals (ARV) for the prevention of mother-to-child transmission, there remains a need for continued monitoring as the intrauterine interval is a critical period during which fetal programming influences the future health and development of the child.

Methods

We conducted a systematic review of the current literature addressing potential metabolic complications of in utero HIV and ARV exposure. We describe studies evaluating metabolic outcomes such as intrauterine and early postnatal growth, bone health and mitochondrial toxicity.

Results

Overall, infants exposed to HIV/ARV do not appear to exhibit vastly compromised intrauterine or early postnatal growth. However, some studies on the

SUBMITTER: Jao J 

PROVIDER: S-EPMC4055505 | biostudies-literature | 2014 Jul

REPOSITORIES: biostudies-literature