An HMM-based comparative genomic framework for detecting introgression in eukaryotes.

ABSTRACT: One outcome of interspecific hybridization and subsequent effects of evolutionary forces is introgression, which is the integration of genetic material from one species into the genome of an individual in another species. The evolution of several groups of eukaryotic species has involved hybridization, and cases of adaptation through introgression have been already established. In this work, we report on PhyloNet-HMM-a new comparative genomic framework for detecting introgression in genomes. PhyloNet-HMM combines phylogenetic networks with hidden Markov models (HMMs) to simultaneously capture the (potentially reticulate) evolutionary history of the genomes and dependencies within genomes. A novel aspect of our work is that it also accounts for incomplete lineage sorting and dependence acro

SUBMITTER: Liu KJ 

PROVIDER: S-EPMC4055573 | biostudies-literature | 2014 Jun

REPOSITORIES: biostudies-literature