Circulating mediators of inflammation and immune activation in AIDS-related non-hodgkin lymphoma.

ABSTRACT:

Background

Non-Hodgkin lymphoma (NHL) is the most common AIDS-related malignancy in developed countries. An elevated risk of developing NHL persists among HIV-infected individuals in comparison to the general population despite the advent of effective antiretroviral therapy. The mechanisms underlying the development of AIDS-related NHL (A-NHL) are not fully understood, but likely involve persistent B-cell activation and inflammation.

Methods

This was a nested case-control study within the ongoing prospective Multicenter AIDS Cohort Study (MACS). Cases included 47 HIV-positive male subjects diagnosed with high-grade B-cell NHL. Controls were matched to each case from among participating HIV-positive males who did not develop any malignancy. Matching criteria included time HIV

SUBMITTER: Nolen BM 

PROVIDER: S-EPMC4055650 | biostudies-literature | 2014

REPOSITORIES: biostudies-literature