Anacardic acid enhances the proliferation of human ovarian cancer cells.

ABSTRACT:

Background

Anacardic acid (AA) is a mixture of 2-hydroxy-6-alkylbenzoic acid homologs. Certain antitumor activities of AA have been reported in a variety of cancers. However, the function of AA in ovarian cancer, to date, has remained unknown.

Methods

Ovarian cancer cell lines were exposed to AA, after which cell proliferation, apoptosis, invasion and migration assays were performed. Phalloidin staining was used to observe lamellipodia formation. Reverse transcription polymerase chain reaction (RT-PCR) and western blotting were used to assess the mRNA and protein expression levels of Phosphatidylinositol 3-kinase (PI3K), vascular endothelial growth factor (VEGF) and caspase 3.

Results

Our results showed that AA promotes ovarian cancer cell proliferation, inhibits late

SUBMITTER: Xiu YL 

PROVIDER: S-EPMC4055655 | biostudies-literature | 2014

REPOSITORIES: biostudies-literature