Bioactivities of Compounds from Elephantopus scaber, an Ethnomedicinal Plant from Southwest China.

ABSTRACT: Elephantopus scaber is an ethnomedicinal plant used by the Zhuang people in Southwest China to treat headaches, colds, diarrhea, hepatitis, and bronchitis. A new δ -truxinate derivative, ethyl, methyl 3,4,3',4'-tetrahydroxy- δ -truxinate (1), was isolated from the ethyl acetate extract of the entire plant, along with 4 known compounds. The antioxidant activity of these 5 compounds was determined by ABTS radical scavenging assay. Compound 1 was also tested for its cytotoxicity effect against HepG2 by MTT assay (IC50 = 60  μ M), and its potential anti-inflammatory, antibiotic, and antitumor bioactivities were predicted using target fishing method software.

SUBMITTER: Wang J 

PROVIDER: S-EPMC4055671 | biostudies-literature | 2014

REPOSITORIES: biostudies-literature