Genetic variants in PVRL2-TOMM40-APOE region are associated with human longevity in a Han Chinese population.

ABSTRACT:

Purpose

Human longevity results from a number of factors, including genetic background, favorable environmental, social factors and chance. In this study, we aimed to elucidate the association of human longevity with genetic variations in several major candidate genes in a Han Chinese population.

Methods

A case-control association study of 1015 long-lived individuals (aged 90 years or older) and 1725 younger controls (30-70 years old) was undertaken. Rs2075650 in TOMM40 was firstly genotyped using the ABI SNaPshot method in an initial cohort consisted of 597 unrelated long-lived individuals and 1275 younger controls enrolled from Sichuan. Secondly, eighteen tag single-nucleotide polymorphisms (SNPs) in the PVRL2-TOMM40-APOE locus were genotyped for extensive study in the sam

SUBMITTER: Lu F 

PROVIDER: S-EPMC4055715 | biostudies-literature | 2014

REPOSITORIES: biostudies-literature