Disruption of structure-function coupling in the schizophrenia connectome.

ABSTRACT: Neuroimaging studies have demonstrated that the phenomenology of schizophrenia maps onto diffuse alterations in large-scale functional and structural brain networks. However, the relationship between structural and functional deficits remains unclear. To answer this question, patients with established schizophrenia and matched healthy controls underwent resting-state functional and diffusion weighted imaging. The network-based statistic was used to characterize between-group differences in whole-brain functional connectivity. Indices of white matter integrity were then estimated to assess the structural correlates of the functional alterations observed in patients. Finally, group differences in the relationship between indices of functional and structural brain connectivity were determined

SUBMITTER: Cocchi L 

PROVIDER: S-EPMC4055899 | biostudies-literature | 2014

REPOSITORIES: biostudies-literature