Sequence analysis on the information of folding initiation segments in ferredoxin-like fold proteins.

ABSTRACT:

Background

While some studies have shown that the 3D protein structures are more conservative than their amino acid sequences, other experimental studies have shown that even if two proteins share the same topology, they may have different folding pathways. There are many studies investigating this issue with molecular dynamics or Go-like model simulations, however, one should be able to obtain the same information by analyzing the proteins' amino acid sequences, if the sequences contain all the information about the 3D structures. In this study, we use information about protein sequences to predict the location of their folding segments. We focus on proteins with a ferredoxin-like fold, which has a characteristic topology. Some of these proteins have different folding segments.

SUBMITTER: Matsuoka M 

PROVIDER: S-EPMC4055915 | biostudies-literature | 2014 May

REPOSITORIES: biostudies-literature