Tropomyosin-related receptor kinase B at the invasive front and tumour cell dedifferentiation in gastric cancer.

ABSTRACT:

Background

Tropomyosin-related receptor kinase B (TrkB) promotes proliferation and invasion, relating to poor prognosis of various malignancies. We examined the role of TrkB at the invasive front of gastric cancer (GC) and its association with tumour cell dedifferentiation and tumour budding.

Methods

Immunoreactive TrkB was evaluated at the tumour centre and margin using whole-tissue sections of 320 GC patients. Tumour cell dedifferentiation was defined as higher histologic grade at the tumour margin than the surface or tumour centre. Tumour budding was also scored on cytokeratin-stained sections.

Results

Sixty-five patients (20%) showed higher TrkB expression at the invasive front (TrkB expression was higher at the tumour margin than tumour centre). It was significan

SUBMITTER: Tanaka K 

PROVIDER: S-EPMC4056051 | biostudies-literature | 2014 Jun

REPOSITORIES: biostudies-literature