Multi-colour FISH in oesophageal adenocarcinoma-predictors of prognosis independent of stage and grade.

ABSTRACT:

Background

Oesophageal adenocarcinoma or Barrett's adenocarcinoma (EAC) is increasing in incidence and stratification of prognosis might improve disease management. Multi-colour fluorescence in situ hybridisation (FISH) investigating ERBB2, MYC, CDKN2A and ZNF217 has recently shown promising results for the diagnosis of dysplasia and cancer using cytological samples.

Methods

To identify markers of prognosis we targeted four selected gene loci using multi-colour FISH applied to a tissue microarray containing 130 EAC samples. Prognostic predictors (P1, P2, P3) based on genomic copy numbers of the four loci were statistically assessed to stratify patients according to overall survival in combination with clinical data.

Results

The best stratification into favourable and

SUBMITTER: Geppert CI 

PROVIDER: S-EPMC4056055 | biostudies-literature | 2014 Jun

REPOSITORIES: biostudies-literature