Double impact of cigarette smoke and mechanical ventilation on the alveolar epithelial type II cell.

ABSTRACT:

Introduction

Ventilator-induced lung injury (VILI) impacts clinical outcomes in acute respiratory distress syndrome (ARDS), which is characterized by neutrophil-mediated inflammation and loss of alveolar barrier function. Recent epidemiological studies suggest that smoking may be a risk factor for the development of ARDS. Because alveolar type II cells are central to maintaining the alveolar epithelial barrier during oxidative stress, mediated in part by neutrophilic inflammation and mechanical ventilation, we hypothesized that exposure to cigarette smoke and mechanical strain have interactive effects leading to the activation of and damage to alveolar type II cells.

Methods

To determine if cigarette smoke increases susceptibility to VILI in vivo, a clinically relevant rat m

SUBMITTER: Hirsch J 

PROVIDER: S-EPMC4056080 | biostudies-literature | 2014 Mar

REPOSITORIES: biostudies-literature