Endogenous glutamine production in critically ill patients: the effect of exogenous glutamine supplementation.

ABSTRACT:

Introduction

Glutamine rate of appearance (Ra) may be used as an estimate of endogenous glutamine production. Recently a technique employing a bolus injection of isotopically labeled glutamine was introduced, with the potential to allow for multiple assessments of the glutamine Ra over time in critically ill patients, who may not be as metabolically stable as healthy individuals. Here the technique was used to evaluate the endogenous glutamine production in critically ill patients in the fed state with and without exogenous glutamine supplementation intravenously.

Methods

Mechanically ventilated patients (n = 11) in the intensive care unit (ICU) were studied on two consecutive days during continuous parenteral feeding. To allow the patients to be used as their own controls,

SUBMITTER: Mori M 

PROVIDER: S-EPMC4056090 | biostudies-literature | 2014 Apr

REPOSITORIES: biostudies-literature