Widespread promoter-mediated coordination of transcription and mRNA degradation.

ABSTRACT:

Background

Previous work showed that mRNA degradation is coordinated with transcription in yeast, and in several genes the control of mRNA degradation was linked to promoter elements through two different mechanisms. Here we show at the genomic scale that the coordination of transcription and mRNA degradation is promoter-dependent in yeast and is also observed in humans.

Results

We first demonstrate that swapping upstream cis-regulatory sequences between two yeast species affects both transcription and mRNA degradation and suggest that while some cis-regulatory elements control either transcription or degradation, multiple other elements enhance both processes. Second, we show that adjacent yeast genes that share a promoter (through divergent orientation) have increased simi

SUBMITTER: Dori-Bachash M 

PROVIDER: S-EPMC4056365 | biostudies-literature | 2012 Dec

REPOSITORIES: biostudies-literature