Hyperglycemia-induced diaphragm weakness is mediated by oxidative stress.

ABSTRACT:

Introduction

A major consequence of ICU-acquired weakness (ICUAW) is diaphragm weakness, which prolongs the duration of mechanical ventilation. Hyperglycemia (HG) is a risk factor for ICUAW. However, the mechanisms underlying HG-induced respiratory muscle weakness are not known. Excessive reactive oxygen species (ROS) injure multiple tissues during HG, but only one study suggests that excessive ROS generation may be linked to HG-induced diaphragm weakness. We hypothesized that HG-induced diaphragm dysfunction is mediated by excessive superoxide generation and that administration of a specific superoxide scavenger, polyethylene glycol superoxide dismutase (PEG-SOD), would ameliorate these effects.

Methods

HG was induced in rats using streptozotocin (60 mg/kg intravenously) an

SUBMITTER: Callahan LA 

PROVIDER: S-EPMC4056378 | biostudies-literature | 2014 May

REPOSITORIES: biostudies-literature