Induced expression and functional effects of aquaporin-1 in human leukocytes in sepsis.

ABSTRACT:

Introduction

Gene expression profiling was performed via DNA microarrays in leukocytes from critically ill trauma patients nonseptic upon admission to the ICU, who subsequently developed either sepsis (n = 2) or severe sepsis and acute respiratory distress syndrome (n = 3). By comparing our results with published expression profiling studies in animal models of sepsis and lung injury, we found aquaporin-1 to be differentially expressed across all studies. Our aim was to determine how the water channel aquaporin-1 is involved in regulating the immune response in critically ill patients during infection acquired in the ICU.

Methods

Following the results of the initial genetic screening study, we prospectively followed aquaporin-1 leukocyte expression patterns in patients with

SUBMITTER: Vassiliou AG 

PROVIDER: S-EPMC4056620 | biostudies-literature | 2013 Sep

REPOSITORIES: biostudies-literature