Platelet mitochondrial membrane depolarization reflects disease severity in patients with sepsis and correlates with clinical outcome.

ABSTRACT:

Introduction

Sepsis is still a leading cause of morbidity and mortality, even in modern times, and thrombocytopenia has been closely associated with unfavorable disease outcome. Decreases in mitochondrial membrane potential (depolarization) were found in different tissues during sepsis. Previous work suggests that mitochondrial dysfunction of platelets correlates with clinical disease activity in sepsis. However, platelet mitochondrial membrane potential (Mmp) has not been investigated in a clinical follow-up design and not with regard to disease outcome.

Methods

In this study, platelet mitochondrial membrane depolarization was assessed by means of a fluorescent Mmp-Index with flow cytometry in 26 patients with sepsis compared with control patients. Platelet Mmp-Index on adm

SUBMITTER: Grundler K 

PROVIDER: S-EPMC4056796 | biostudies-literature | 2014 Feb

REPOSITORIES: biostudies-literature