Open lung approach with low tidal volume mechanical ventilation attenuates lung injury in rats with massive brain damage.

ABSTRACT:

Introduction

The ideal ventilation strategy for patients with massive brain damage requires better elucidation. We hypothesized that in the presence of massive brain injury, a ventilation strategy using low (6 milliliters per kilogram ideal body weight) tidal volume (V(T)) ventilation with open lung positive end-expiratory pressure (LV(T)/OLPEEP) set according to the minimal static elastance of the respiratory system, attenuates the impact of massive brain damage on gas-exchange, respiratory mechanics, lung histology and whole genome alterations compared with high (12 milliliters per kilogram ideal body weight) V(T) and low positive end-expiratory pressure ventilation (HV(T)/LPEEP).

Methods

In total, 28 adult male Wistar rats were randomly assigned to one of four groups: 1)

SUBMITTER: Krebs J 

PROVIDER: S-EPMC4056811 | biostudies-literature | 2014 Apr

REPOSITORIES: biostudies-literature