On the crucial cerebellar wound healing-related pathways and their cross-talks after traumatic brain injury in Danio rerio.

ABSTRACT: Upon injury, the direct damage and the subsequent secondary injury in the brain often result in chronic neurological disorders. Due to multifactorial nature of secondary injury and subsequent complex cellular responses, much of the underlying mechanisms are unclear. This study used an adult zebrafish cerebellum injury model to investigate the phenotypes and the secondary injury responses for recovery mechanisms of injured brain. Using the time course microarray analysis, a candidate protein-protein interaction (PPI) network was refined as cerebellar wound healing PPI network by dynamic modeling and big data mining. Pathway enrichment and ontological analysis were incorporated into the refined network to highlight the main molecular scheme of cerebellar wound healing. Several significant pa

SUBMITTER: Wu CC 

PROVIDER: S-EPMC4057083 | biostudies-literature | 2014

REPOSITORIES: biostudies-literature