Epiregulin enhances tumorigenicity by activating the ERK/MAPK pathway in glioblastoma.

ABSTRACT:

Background

Glioblastoma multiforme (GBM) is one of the most aggressive human tumors, and the establishment of an effective therapeutic reagent is a pressing priority. Recently, it has been shown that the tumor tissue consists of heterogeneous components and that a highly aggressive population should be the therapeutic target.

Methods

Through a single subcutaneous passage of GBM cell lines LN443 and U373 in mice, we have developed highly aggressive variants of these cells named LN443X, U373X1, and U373X2, which showed increased tumor growth, colony-forming potential, sphere-forming potential, and invasion ability. We further investigated using microarray analysis comparing malignant cells with their parental cells and mRNA expression analysis in grades II to IV glioma samples

SUBMITTER: Kohsaka S 

PROVIDER: S-EPMC4057138 | biostudies-literature | 2014 Jul

REPOSITORIES: biostudies-literature