The microtubule associated protein tau H1 haplotype and risk of essential tremor.

ABSTRACT:

Background and purpose

Two recent studies investigated the association of the microtubule associated protein tau (MAPT) H1 haplotype, a known risk factor for neurodegenerative disease including progressive supranuclear palsy and Parkinson's disease (PD), with essential tremor (ET).

Methods

To confirm this association in a different population the distribution of allele and genotype frequencies for the MAPT H1/H2 tagging single-nucleotide polymorphism (SNP) rs1052553 in ET cases and controls enrolled in a clinical-epidemiological study of ET at Columbia University was analyzed.

Results

Overall, no association was observed between ET and the MAPT H1 haplotype. The analysis was also restricted to clinical subtypes including early-onset (≤40 years of age), Ashkenazi Jewis

SUBMITTER: Clark LN 

PROVIDER: S-EPMC4057305 | biostudies-literature | 2014 Jul

REPOSITORIES: biostudies-literature