Retinopathy of prematurity and brain damage in the very preterm newborn.

ABSTRACT:

Purpose

To explain why very preterm newborns who develop retinopathy of prematurity (ROP) appear to be at increased risk of abnormalities of both brain structure and function.

Methods

A total of 1,085 children born at <28 weeks' gestation had clinically indicated retinal examinations and had a developmental assessment at 2 years corrected age. Relationships between ROP categories and brain abnormalities were explored using logistic regression models with adjustment for potential confounders.

Results

The 173 children who had severe ROP, defined as prethreshold ROP (n = 146) or worse (n = 27) were somewhat more likely than their peers without ROP to have brain ultrasound lesions or cerebral palsy. They were approximately twice as likely to have very low Bayley Scales sc

SUBMITTER: Allred EN 

PROVIDER: S-EPMC4057649 | biostudies-literature | 2014 Jun

REPOSITORIES: biostudies-literature