Molecular characterization of Clonorchis sinensis secretory myoglobin: delineating its role in anti-oxidative survival.

ABSTRACT:

Background

Clonorchiasis is a globally important, neglected food-borne disease caused by Clonorchis sinensis (C. sinensis), and it is highly related to cholangiocarcinoma and hepatocellular carcinoma. Increased molecular evidence has strongly suggested that the adult worm of C. sinensis continuously releases excretory-secretory proteins (ESPs), which play important roles in the parasite-host interactions, to establish successful infection and ensure its own survival. Myoglobin, a hemoprotein, is present in high concentrations in trematodes and ESPs. To further understand the biological function of CsMb and its putative roles in the interactions of C. sinensis with its host, we explored the molecular characterization of CsMb in this paper.

Methods

We expressed CsMb and its mu

SUBMITTER: Ren M 

PROVIDER: S-EPMC4057808 | biostudies-literature | 2014 May

REPOSITORIES: biostudies-literature