Infection with dengue-2 virus alters proteins in naturally expectorated saliva of Aedes aegypti mosquitoes.

ABSTRACT:

Background

Dengue virus (DENV) is responsible for up to approximately 300 million infections and an increasing number of deaths related to severe manifestations each year in affected countries throughout the tropics. It is critical to understand the drivers of this emergence, including the role of vector-virus interactions. When a DENV-infected Aedes aegypti mosquito bites a vertebrate, the virus is deposited along with a complex mixture of salivary proteins. However, the influence of a DENV infection upon the expectorated salivary proteome of its vector has yet to be determined.

Methods

Therefore, we conducted a proteomic analysis using 2-D gel electrophoresis coupled with mass spectrometry based protein identification comparing the naturally expectorated saliva of Aedes ae

SUBMITTER: Chisenhall DM 

PROVIDER: S-EPMC4057903 | biostudies-literature | 2014 May

REPOSITORIES: biostudies-literature