Cerebrospinal fluid biomarkers in clinical subtypes of early-onset Alzheimer's disease.

ABSTRACT: Accurate diagnosis of sporadic early-onset Alzheimer's disease (EOAD) can be challenging, and cerebrospinal fluid (CSF) biomarkers may assist in this process. We compared CSF indices between three EOAD subtypes: amnestic, logopenic progressive aphasia (LPA), and posterior cortical atrophy (PCA).We identified 21 amnestic EOAD, 20 LPA, and 12 PCA patients with CSF data, which included amyloid ?1-42 (A?42), total tau (t-tau), phospho-tau181 (p-tau), and A?42/t-tau index (ATI) levels.A?42 and ATI levels were similar across groups, but t-tau and p-tau levels were significantly lower in PCA patients.The A?42 and ATI data confirm the commonality of the A? pathology in EOAD. The lower tau indices in PCA patients may reflect differences in the distribution of neurofibrillary tangles or rates of neurodegeneration.

SUBMITTER: Teng E 

PROVIDER: S-EPMC4057962 | biostudies-literature | 2014

REPOSITORIES: biostudies-literature