Cry1 and Tef gene polymorphisms are associated with major depressive disorder in the Chinese population.

ABSTRACT:

Introduction

Accumulating evidences indicate that circadian abnormalities lead to sleep disorder, neurodegenerative diseases and depression. We have reported that the polymorphisms of a clock-related gene, Tef, contributed to the risk of sleep disturbances and depression in the Parkinson disease. The objective of the present study was to examine whether the three clock genes we previously studied are associated with major depressive disorder (MDD) in the Chinese population.

Methods

105 Subjects with MDD and 485 control subjects participated in this case-control study. Demographics, Mini-mental Status Examination (MMSE), and the Hamilton rating scale for depression (HAMD) were obtained in all subjects. Genotypes of single nucleotide polymorphisms (SNPs) of Cry1 rs2287161, Cry

SUBMITTER: Hua P 

PROVIDER: S-EPMC4058073 | biostudies-literature | 2014 Mar

REPOSITORIES: biostudies-literature