Pathway-based analysis of breast cancer.

ABSTRACT:

Introduction

Although HER2 and ER pathways are predominant pathways altered in breast cancer, it is now well accepted that many other signaling pathways are also involved in the pathogenesis of breast cancer. The understanding of these additional pathways may assist in identifying new therapeutic approaches for breast cancer.

Methods

13 invasive ductal carcinoma tissues and 5 benign breast tissues were analyzed for the mRNA expression level of 1243 cancer pathway-related genes using SmartChip (WaferGen, CA), a real-time PCR-base method. In addition, the levels of 131 cancer pathway-related proteins and phosphoproteins in 33 paired breast cancers were measured using our innovative Protein Pathway Array.

Results

Out of 1,243 mRNAs, 68.7% (854) were detected in breast ca

SUBMITTER: Song D 

PROVIDER: S-EPMC4058311 | biostudies-literature | 2014

REPOSITORIES: biostudies-literature