NQO1 overexpression is associated with poor prognosis in squamous cell carcinoma of the uterine cervix.

ABSTRACT:

Background

NQO1 (NAD(P)H: quinone oxidoreductase-1), located on chromosome 16q22, functions primarily to protect normal cells from oxidant stress and electrophilic attack. Recent studies have revealed that NQO1 is expressed at a high level in most human solid tumors including those of the colon, breast, pancreas, ovaries and thyroid, and it has also been detected following the induction of cell cycle progression and proliferation of melanoma cells. In this study, we aimed to investigate the clinicopathological significance of upregulated NQO1 protein expression in squamous cell carcinomas (SCCs) of the uterine cervix.

Methods

The localization of the NQO1 protein was determined in the SiHa cervical squamous cancer cell line using immunofluorescence (IF) staining, and immunohi

SUBMITTER: Ma Y 

PROVIDER: S-EPMC4058702 | biostudies-literature | 2014 Jun

REPOSITORIES: biostudies-literature