Haem homeostasis is regulated by the conserved and concerted functions of HRG-1 proteins.

ABSTRACT: Haems are metalloporphyrins that serve as prosthetic groups for various biological processes including respiration, gas sensing, xenobiotic detoxification, cell differentiation, circadian clock control, metabolic reprogramming and microRNA processing. With a few exceptions, haem is synthesized by a multistep biosynthetic pathway comprising defined intermediates that are highly conserved throughout evolution. Despite our extensive knowledge of haem biosynthesis and degradation, the cellular pathways and molecules that mediate intracellular haem trafficking are unknown. The experimental setback in identifying haem trafficking pathways has been the inability to dissociate the highly regulated cellular synthesis and degradation of haem from intracellular trafficking events. Caenorhabditis eleg

SUBMITTER: Rajagopal A 

PROVIDER: S-EPMC4058867 | biostudies-literature | 2008 Jun

REPOSITORIES: biostudies-literature