D-Cycloserine as an augmentation strategy with cognitive-behavioral therapy for social anxiety disorder.

ABSTRACT:

Objective

The authors examined whether D-cycloserine, a partial agonist at the glutamatergic N-methyl-d-aspartate receptor, augments and accelerates a full course of comprehensive cognitive-behavioral therapy (CBT) in adults with generalized social anxiety disorder.

Method

This was a multisite randomized placebo-controlled efficacy study with 169 medication-free adults with generalized social anxiety disorder, of whom 144 completed the 12-week treatment and 131 completed the three follow-up assessments. Patients were randomly assigned to receive 50 mg of D-cycloserine or placebo 1 hour before each of five exposure sessions that were part of a 12-session cognitive-behavioral group treatment. Response and remission status was determined at baseline, throughout treatment, at en

SUBMITTER: Hofmann SG 

PROVIDER: S-EPMC4058999 | biostudies-literature | 2013 Jul

REPOSITORIES: biostudies-literature