Rab4 orchestrates a small GTPase cascade for recruitment of adaptor proteins to early endosomes.

ABSTRACT:

Background

Early, sorting endosomes are a major crossroad of membrane traffic, at the intersection of the endocytic and exocytic pathways. The sorting of endosomal cargo for delivery to different subcellular destinations is mediated by a number of distinct coat protein complexes, including adaptor protein 1 (AP-1), AP-3, and Golgi-localized, gamma adaptin ear-containing, Arf-binding (GGAs) protein. Ultrastructural studies suggest that these coats assemble onto tubular subdomains of the endosomal membrane, but the mechanisms of coat recruitment and assembly at this site remain poorly understood.

Results

Here we report that the endosomal Rab protein Rab4 orchestrates a GTPase cascade that results in the sequential recruitment of the ADP-ribosylation factor (Arf)-like protein A

SUBMITTER: D'Souza RS 

PROVIDER: S-EPMC4059052 | biostudies-literature | 2014 Jun

REPOSITORIES: biostudies-literature