The LRP6 rs2302685 polymorphism is associated with increased risk of myocardial infarction.

ABSTRACT:

Background

Abnormal lipids is one of the critical risk factors for myocardial infarction (MI), however the role of genetic variants in lipid metabolism-related genes on MI pathogenesis still requires further investigation. We herein genotyped three SNPs (LRP6 rs2302685, LDLRAP1 rs6687605, SOAT1 rs13306731) in lipid metabolism-related genes, aimed to shed light on the influence of these SNPs on individual susceptibility to MI.

Methods

Genotyping of the three SNPs (rs2302685, rs6687605 and rs13306731) was performed in 285 MI cases and 650 control subjects using polymerase chain reaction-ligation detection reaction (PCR-LDR) method. The association of these SNPs with MI and lipid profiles was performed with SPSS software.

Results

Multivariate logistic regression analysis

SUBMITTER: Xu S 

PROVIDER: S-EPMC4059096 | biostudies-literature | 2014 Jun

REPOSITORIES: biostudies-literature