Total synthesis of the antitumor natural product polycarcin V and evaluation of its DNA binding profile.

ABSTRACT: The convergent total synthesis of polycarcin V, a gilvocarcin-type natural product that shows significant cytotoxicity with selectivity for nonsmall-cell lung cancer, breast cancer, and melanoma cells, has been achieved in 13 steps from 7, 8, and 22; the sequence features a stereoselective α-C-glycosylation reaction for the union of protected carbohydrate 7 and naphthol 8. The association constant for the binding of polycarcin V to duplex DNA is similar to that previously reported for gilvocarcin V.

SUBMITTER: Cai X 

PROVIDER: S-EPMC4059221 | biostudies-literature | 2014 Jun

REPOSITORIES: biostudies-literature