Heart rate variability on antihypertensive drugs in black patients living in sub-Saharan Africa.

ABSTRACT:

Background

Compared with Caucasians, African Americans have lower heart rate variability (HRV) in the high-frequency domain, but there are no studies in blacks born and living in Africa.

Methods

In the Newer versus Older Antihypertensive agents in African Hypertensive patients trial (NCT01030458), patients (30-69 years) with uncomplicated hypertension (140-179/90-109 mmHg) were randomized to single-pill combinations of bisoprolol/hydrochlorothiazide (R) or amlodipine/valsartan (E). 72 R and 84 E patients underwent 5-min ECG recordings at randomization and 8, 16 and 24 weeks. HRV was determined by fast Fourier transform and autoregressive modelling.

Results

Heart rate decreased by 9.5 beats/min in R patients with no change in E patients (- 2.2 beats/min). R patients ha

SUBMITTER: Osakwe CE 

PROVIDER: S-EPMC4059227 | biostudies-literature | 2014 Jun

REPOSITORIES: biostudies-literature