Evidence that natural selection on codon usage in Drosophila pseudoobscura varies across codons.

ABSTRACT: Like other species of Drosophila, Drosophila pseudoobscura has a distinct bias toward the usage of C- and G-ending codons. Previous studies have indicated that this bias is due, at least in part, to natural selection. Codon bias clearly differs among amino acids (and other codon classes) in Drosophila, which may reflect differences in the intensity of selection on codon usage. Ongoing natural selection on synonymous codon usage should be reflected in the shapes of the site frequency spectra of derived states at polymorphic positions. Specifically, regardless of other demographic effects on the spectrum, it should be shifted toward higher values for changes from less-preferred to more-preferred codons, and toward lower values for the converse. If the intensity of natural selection is increa

SUBMITTER: Kliman RM 

PROVIDER: S-EPMC4059240 | biostudies-literature | 2014 Apr

REPOSITORIES: biostudies-literature