Guidelines for therapeutic drug monitoring of vancomycin: a systematic review.

ABSTRACT:

Background and objective

Despite the availability of clinical practice guidelines (CPGs) for therapeutic drug monitoring (TDM) of vancomycin, vancomycin serum concentrations still do not reach therapeutic concentrations in many patients. Thus, we sought to systematically review the quality and consistency of recommendations for an international cohort of CPGs regarding vancomycin TDM.

Methods

PubMed, Embase, guidelines' websites and Google were searched for CPGs for vancomycin TDM. Two independent assessors rated the quality of each CPG using the Appraisal of Guidelines for Research & Evaluation II (AGREEII) instrument and data were independently extracted.

Results

Twelve guidelines were evaluated and the overall quality of guidelines for vancomycin TDM was moderate.

SUBMITTER: Ye ZK 

PROVIDER: S-EPMC4059638 | biostudies-literature | 2014

REPOSITORIES: biostudies-literature