Increases in myocardial workload induced by rapid atrial pacing trigger alterations in global metabolism.

ABSTRACT:

Objective

To determine whether increases in cardiac work lead to alterations in the plasma metabolome and whether such changes arise from the heart or peripheral organs.

Background

There is growing evidence that the heart influences systemic metabolism through endocrine effects and affecting pathways involved in energy homeostasis.

Methods

Nineteen patients referred for cardiac catheterization were enrolled. Peripheral and selective coronary sinus (CS) blood sampling was performed at serial timepoints following the initiation of pacing, and metabolite profiling was performed by liquid chromatography-mass spectrometry (LC-MS).

Results

Pacing-stress resulted in a 225% increase in the median rate·pressure product from baseline. Increased myocardial work induced si

SUBMITTER: Turer AT 

PROVIDER: S-EPMC4059652 | biostudies-literature | 2014

REPOSITORIES: biostudies-literature