Disturbed anterior prefrontal control of the mesolimbic reward system and increased impulsivity in bipolar disorder.

ABSTRACT: Bipolar disorder (BD) is characterized by recurrent mood episodes ranging from severe depression to acute full-blown mania. Both states of this severe psychiatric disorder have been associated with alterations of reward processing in the brain. Here, we present results of a functional magnetic resonance imaging (fMRI) study on the neural correlates and functional interactions underlying reward gain processing and reward dismissal in favor of a long-term goal in bipolar patients. Sixteen medicated patients diagnosed with bipolar I disorder, euthymic to mildly depressed, and sixteen matched healthy controls performed the 'desire-reason dilemma' (DRD) paradigm demanding rejection of priorly conditioned reward stimuli to successfully pursue a superordinate goal. Both groups exhibited significa

SUBMITTER: Trost S 

PROVIDER: S-EPMC4059900 | biostudies-literature | 2014 Jul

REPOSITORIES: biostudies-literature