Replication of the effect of SLC2A9 genetic variation on serum uric acid levels in American Indians.

ABSTRACT: Increased serum uric acid (SUA) or hyperuricemia, a risk factor for gout, renal and cardiovascular diseases, is caused by either increased production or decreased excretion of uric acid or a mix of both. The solute carrier protein 2 family, member 9 (SLC2A9) gene encodes a transporter that mediates urate flux across the renal proximal tubule. Genome-wide association studies have consistently shown the association of single-nucleotide polymorphisms in this gene with SUA in majority populations. American Indian participants of the Strong Heart Family Study, belonging to multigenerational families, have high prevalence of hyperuricemia. We conducted measured genotype analyses, based on variance components decomposition method and accounting for family relationships, to assess whether the asso

SUBMITTER: Voruganti VS 

PROVIDER: S-EPMC4060115 | biostudies-literature | 2014 Jul

REPOSITORIES: biostudies-literature