Distribution of ancestral chromosomal segments in admixed genomes and its implications for inferring population history and admixture mapping.

ABSTRACT: The ancestral chromosomal segments in admixed genomes are of significant importance for both population history inference and admixture mapping, because they essentially provide the basic information for tracking genetic events. However, the distributions of the lengths of ancestral chromosomal segments (LACS) under some admixture models remain poorly understood. Here we introduced a theoretical framework on the distribution of LACS in two representative admixture models, that is, hybrid isolation (HI) model and gradual admixture (GA) model. Although the distribution of LACS in the GA model differs from that in the HI model, we demonstrated that the mean LACS in the HI model is approximately half of that in the GA model if both admixture proportion and admixture time in the two models are

SUBMITTER: Jin W 

PROVIDER: S-EPMC4060116 | biostudies-literature | 2014 Jul

REPOSITORIES: biostudies-literature